Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 675
interventional 522
Observational 129
Registry 24

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 112
Procedure 87
Drug|Procedure|Radiation 49
Drug|Radiation 41
Radiation 27
Device 24
Drug|Other 22
Other 21
Drug|Procedure 16
Behavioral 13
Biological|Drug 11
Biological|Drug|Other 11
Drug|placebo 9
Biological|Drug|Procedure|Radiation 6
Drug|Other|Radiation 6
Biological 5
Other|Procedure 5
Device|Drug 4
Device|Procedure 4
Drug|Other|Procedure|Radiation 4
Procedure|Radiation 4
Behavioral|Other 3
Biological|Drug|Radiation 3
Diagnostic Test 3
Dietary Supplement 3
Drug|Other|Procedure 3
Biological|Drug|Other|Procedure|Radiation 2
Combination Product 2
Device|Drug|Radiation 2
Device|Other|Procedure 2
Drug|placebo|Radiation 2
Behavioral|Drug|Procedure|Radiation 1
Behavioral|Other|Procedure 1
Behavioral|Procedure 1
Biological|Device|Drug|Other 1
Biological|Device|Procedure 1
Biological|Drug|Other|Radiation 1
Biological|Other 1
Combination Product|Drug 1
Device|Drug|Other|Procedure 1
Device|Other 1
Diagnostic Test|Other 1
Dietary Supplement|Drug 1
Dietary Supplement|Drug|Other|placebo|Radiation 1
Drug|Genetic|Other|Procedure|Radiation 1
Drug|Genetic|Other|Radiation 1
Drug|Other|placebo 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 164
China 68
France 32
NA 28
Korea, Republic of 22
Canada 16
Germany 14
Italy 14
Netherlands 14
Spain 14
United Kingdom 14
Denmark 12
Sweden 9
Russian Federation 7
United States|Canada 6
Australia 5
Belgium 4
Brazil 4
Israel 4
Japan 4
Switzerland 4
Austria 3
Hong Kong 3
Norway 3
Saudi Arabia 3
Taiwan 3
Finland 2
Hungary|Switzerland 2
Poland 2
Portugal 2
Slovenia 2
United States|Puerto Rico 2
Australia|New Zealand 1
Belgium|France|Germany|Israel|Netherlands|Poland|Serbia|Spain|Switzerland|Turkey 1
Belgium|France|Germany|Italy|Netherlands|Spain|United Kingdom 1
Belgium|France|Monaco 1
Belgium|Israel|Sweden 1
Canada|United Kingdom 1
China|Poland|Sweden 1
Denmark|France|Sweden|United Kingdom 1
Denmark|Netherlands|United Kingdom 1
Egypt 1
Egypt|Italy 1
Finland|Sweden 1
Germany|Switzerland 1
India|Poland|Romania|Serbia|United Kingdom 1
Ireland 1
Italy|Spain 1
Jordan|Lebanon 1
Lithuania 1
Slovakia 1
Turkey 1
United States|Argentina|Australia|Brazil|Russian Federation|Ukraine 1
United States|Australia 1
United States|Australia|Austria|Belgium|Brazil|Canada|France|Germany|Hong Kong|Italy|New Zealand|Portugal|Slovakia|Spain|Sweden|Switzerland|Taiwan|United Kingdom 1
United States|Belgium 1
United States|Belgium|Canada|Germany|Italy|Spain 1
United States|Belgium|Denmark|Israel|Italy|Netherlands|Sweden 1
United States|Canada|Israel|Switzerland 1
United States|Canada|Puerto Rico 1
United States|Canada|South Africa 1
United States|Denmark|Netherlands|Norway|Slovenia|Spain|Sweden 1
United States|Former Serbia and Montenegro 1
United States|Germany|Hungary|Sweden|Switzerland 1
United States|Poland|United Kingdom 1
United States|Spain 1
United States|Switzerland|Australia|Belgium|Brazil|Canada|Czechia|France|Germany|Hungary|Italy|Netherlands|New Zealand|Portugal|Slovakia|Spain|Sweden|Taiwan|United Kingdom 1
Vietnam 1

Sites per Study

Site_count Study_Count
1 348
2 42
3 12
4 11
5 6
6 10
7 7
8 7
9 6
10 5
11 7
12 5
13 2
14 5
15 3
17 1
18 2
19 2
20 1
21 1
22 2
24 1
26 1
29 1
30 2
34 1
35 1
36 1
37 4
38 1
39 1
40 2
41 1
43 1
45 1
48 1
56 1
61 1
67 1
72 1
89 1
95 1
107 1
112 1
120 1
130 1
180 1
211 1
223 1
251 1
756 1
1073 1
1329 1

Phase

Phase Study_Count
Phase 2 176
N/A 170
Phase 3 66
Phase 1 57
Phase 1/Phase 2 37
Phase 4 7
Phase 2/Phase 3 6
Early Phase 1 3

Number of Arms

Number_of_Arms Count_of_Studies
1 240
2 212
3 18
4 14
5 3
6 1
37 1
NA 33

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 12.00000 1.0000 3.00000 13.00000 13.0000 48.0000 11.0000 23.000
1st Qu. 12.00000 32.5000 17.00000 32.00000 34.2500 69.7500 221.2500 51.000
Median 12.00000 100.0000 20.00000 44.00000 55.0000 214.0000 439.0000 80.000
Mean 22.33333 207.2176 27.48148 65.05405 115.7644 428.8333 515.5758 1198.571
3rd Qu. 27.50000 200.0000 31.75000 75.00000 90.7500 714.5000 742.0000 92.500
Max. 43.00000 2800.0000 147.00000 268.00000 6452.0000 1194.0000 1917.0000 8000.000

Trial Group Type

group_type Group_Count
Experimental 572
Active Comparator 161
Other 41
No Intervention 38
NA 33
Placebo Comparator 17
Sham Comparator 3

Intervention Model

intervention_model Study_Count
Single Group Assignment 271
Parallel Assignment 225
NA 11
Crossover Assignment 7
Sequential Assignment 5
Factorial Assignment 3

Primary Purpose

primary_purpose Study_Count
Treatment 416
Diagnostic 34
Supportive Care 22
Prevention 18
Other 12
Health Services Research 7
Screening 6
Basic Science 4
NA 3

Observational Studies

Studies by Country

Country Study_Count
United States 29
China 18
NA 11
Sweden 11
Korea, Republic of 7
Denmark 6
Norway 5
Switzerland 5
Italy 4
United Kingdom 4
France 3
Germany 3
Morocco 3
Netherlands 3
Spain 2
Thailand 2
Algeria|Morocco 1
Austria 1
Brazil 1
Denmark|Sweden|United Kingdom 1
Finland 1
Germany|Serbia|United Kingdom 1
Pakistan 1
Poland 1
Russian Federation 1
Saudi Arabia 1
United States|Austria|Belgium|France|Japan|Poland 1
United States|Canada 1
United States|Canada|Germany 1

Sites per Study

Site_count Study_Count
1 94
2 10
3 6
4 1
5 2
7 2
8 4
9 1
10 1
16 1
17 1
19 1
20 1
37 1
200 1
537 1
716 1

Enrollment Metrics

Measure Observational
Min 3.0000
1st Qu 60.0000
Median 133.0000
Mean 376.7812
3rd Qu 316.2500
Max 13000.0000

Observation Model

observational_model Study_Count
Cohort 77
Case-Only 22
Case-Control 12
Case Control 7
Other 7
NA 3
Case Control, Natural History 1

Time Perspective

time_perspective Study_Count
Prospective 95
Retrospective 28
Cross-Sectional 2
Other 2
Cross-Sectional, Prospective 1
NA 1

Registries

Studies by Country

Country Study_Count
China 3
United States 3
Denmark 2
France 2
Netherlands 2
Australia|France 1
Belgium|Netherlands 1
Brazil 1
Canada 1
Denmark|United Kingdom 1
Israel 1
NA 1
Norway 1
Spain 1
Taiwan 1
Turkey 1
United States|Canada 1

Sites per Study

Site_count Study_Count
1 17
2 3
12 1
14 1
19 1
30 1

Enrollment Metrics

Measure Registries
Min 2.000
1st Qu 70.000
Median 210.000
Mean 2487.708
3rd Qu 1937.500
Max 31795.000

Registry Model

observational_model Study_Count
Cohort 17
Case-Only 5
Case-Control 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 21
Cross-Sectional 2
Other 1

Follow-up

target_duration Study_Count
3 Years 5
5 Years 5
1 Month 4
2 Years 3
1 Year 2
12 Months 1
3 Days 1
30 Days 1
36 Months 1
6 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03392584 Detection and Inflammatory Characterization of Deep Infection After Surgery for Locally Advanced Rectal Cancer With Microdialysis Catheters https://ClinicalTrials.gov/show/NCT03392584 Recruiting Oslo University Hospital 2020-12-31
NCT03328065 Viewpoints on the Social Representations and Rationale Concerning the Choices of Patients, Doctors and Caregivers With Regard to the Management of Patients With Non-resectable Metastatic Cancer of the Colon, Stomach, Bile Ducts, Rectum or Lung, or Gastrointestinal Neuroendocrine Tumours https://ClinicalTrials.gov/show/NCT03328065 Recruiting Centre Hospitalier Universitaire Dijon 2020-12-31
NCT04455737 Ex Vivo Intra-arterial Indigo Carmine Injection After Transanal Total Mesorectal Excision https://ClinicalTrials.gov/show/NCT04455737 Completed Cantonal Hospital of St. Gallen 2019-12-31
NCT03283540 Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence https://ClinicalTrials.gov/show/NCT03283540 Recruiting Case Comprehensive Cancer Center 2020-07-31
NCT03263663 Optimization of Individualized Therapy for CRCs With Secondary RESISTance Towards Anti-EGFR Targeted Therapy Using an Avatar Model https://ClinicalTrials.gov/show/NCT03263663 Recruiting Ludwig-Maximilians - University of Munich 2021-01-01
NCT03238885 Predicting Pathological Complete Response of Rectal Cancer With Magnetic Resonance(MR) Radiomics https://ClinicalTrials.gov/show/NCT03238885 Completed Beijing Cancer Hospital 2018-12-18
NCT03151759 MMP-7 Modulation by Short and Long Term Radiotherapy in Rectal Cancer Patients https://ClinicalTrials.gov/show/NCT03151759 Completed Region Skane 2007-03-16
NCT03149978 Tumor Response Prediction in Neoadjuvant Chemoradiation of Locally Advanced Rectal Cancer Using Metabonomics Analysis https://ClinicalTrials.gov/show/NCT03149978 Recruiting Fudan University 2017-12-30
NCT03133286 Radiotherapy Assessments During Intervention ANd Treatment (RADIANT) https://ClinicalTrials.gov/show/NCT03133286 Recruiting DxTerity Diagnostics 2019-09-06
NCT03107650 Preoperative Prediction Model of Pathological Outcomes (Mesorectum Quality and Positive Circumferential Resection Margin) in Patients With Mid-low Rectal Cancer https://ClinicalTrials.gov/show/NCT03107650 Active, not recruiting Institut d’Investigació Biomèdica de Girona Dr. Josep Trueta 2019-07-31
NCT03039595 Ploidy and Stroma in Early Rectal Cancer https://ClinicalTrials.gov/show/NCT03039595 Completed Oxford University Hospitals NHS Trust 2019-05-31
NCT03015168 Prognostic Value of Neutrophil-to-lymphocyte Ratio (NLR) on Rectal Cancer Patients https://ClinicalTrials.gov/show/NCT03015168 Completed General Hospital of Ningxia Medical University 2017-01-31
NCT02874885 Circulating Tumor Cells in Patients With Rectal Cancer https://ClinicalTrials.gov/show/NCT02874885 Recruiting M.D. Anderson Cancer Center 2023-09-30
NCT02863107 Young-Onset Microsatellite-Stable Colorectal Cancer https://ClinicalTrials.gov/show/NCT02863107 Recruiting M.D. Anderson Cancer Center 2022-06-30
NCT02860234 Tailored Operative or Non-operative Management for Low-risk Rectal Cancer After Intensive Neoadjuvant Treatment https://ClinicalTrials.gov/show/NCT02860234 Completed Beijing Cancer Hospital 2019-11-30
NCT02781935 Diffusion-Weighted MRI for Liver Metastasis https://ClinicalTrials.gov/show/NCT02781935 Recruiting European Organisation for Research and Treatment of Cancer - EORTC 2021-11-30
NCT02774447 Day-Case Closure of Loop Ileostomy in Rectal Cancer https://ClinicalTrials.gov/show/NCT02774447 Completed Uppsala University 2020-03-31
NCT02728804 S1417CD Financial Impact Assessment Tool in Patients With Metastatic Colorectal Cancer https://ClinicalTrials.gov/show/NCT02728804 Active, not recruiting Southwest Oncology Group 2020-08-31
NCT02710812 Rectal Sparing Approach After Preoperative Radio and/or Chemotherapy in Patients With Rectal Cancer https://ClinicalTrials.gov/show/NCT02710812 Recruiting University of Padova 2021-01-31
NCT02651701 Rectal Cancer Staging Using Whole Body MR-PET https://ClinicalTrials.gov/show/NCT02651701 Completed Seoul National University Hospital 2017-08-08
NCT02626728 A Prospective Feasibility Study for TAMIS https://ClinicalTrials.gov/show/NCT02626728 Completed Hvidovre University Hospital 2016-09-30
NCT03402477 “Watch and Wait” After Neo-adjuvant Chemoradiotherapy for Primary Locally Advanced Rectal Cancer. https://ClinicalTrials.gov/show/NCT03402477 Recruiting Helse Stavanger HF 2023-12-31
NCT02537340 PET/MR for Staging Rectal Cancer Patients With and Without EMVI-MR https://ClinicalTrials.gov/show/NCT02537340 Completed Instituto do Cancer do Estado de São Paulo 2018-04-30
NCT02532478 Fortune of Temporary Ileostomies in Patients After Rectal Cancer Surgery https://ClinicalTrials.gov/show/NCT02532478 Completed Dr.Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi 2014-02-28
NCT02486094 Study of PRoliferation and Apoptosis in Rectal Cancer, Predictive & Prognostic biOmarkers: Histopathology and Imaging https://ClinicalTrials.gov/show/NCT02486094 Completed Royal Marsden NHS Foundation Trust 2016-09-01
NCT02441153 Timing of Rectal Cancer Resection After Preoperative Chemoradiotherapy https://ClinicalTrials.gov/show/NCT02441153 Completed Health Sciences North Research Institute 2017-12-25
NCT02438839 Curative Chemoradiation of Low Rectal Cancer https://ClinicalTrials.gov/show/NCT02438839 Active, not recruiting Vejle Hospital 2021-12-31
NCT02312284 Observational Study on the Patients With Rectal Cancer https://ClinicalTrials.gov/show/NCT02312284 Completed Chinese Academy of Medical Sciences 2014-11-30
NCT02190656 Anterior Resection Syndrome Following Sphincter-preserving Surgery https://ClinicalTrials.gov/show/NCT02190656 Completed Queen Mary University of London 2015-06-30
NCT02140723 p53 and Response to Preoperative Radiotherapy for T2 and T3 https://ClinicalTrials.gov/show/NCT02140723 Recruiting Medical University of Vienna 2020-06-30
NCT02132858 Genetic Mutations in Blood and Tissue Samples in Predicting Response to Treatment in Patients With Locally Advanced Rectal Cancer Undergoing Chemoradiation https://ClinicalTrials.gov/show/NCT02132858 Active, not recruiting Fox Chase Cancer Center 2018-07-14
NCT02107105 Quality of Life (QOL) Following Surgical Treatment for Rectal Cancer https://ClinicalTrials.gov/show/NCT02107105 Recruiting M.D. Anderson Cancer Center 2025-05-31
NCT02077296 The Predictive Value of Cytokines on Response to Preoperative Chemoradiotherapy in Patients With Rectal Cancer https://ClinicalTrials.gov/show/NCT02077296 Completed St. Antonius Hospital 2016-08-31
NCT01310985 A Trial of Pre-Operative Chemoradiotherapy Using Capecitabine, Radiation & Cetuximab, in Rectal Cancer https://ClinicalTrials.gov/show/NCT01310985 Completed King Faisal Specialist Hospital & Research Center 2014-08-31
NCT01296984 Oncological and Functional Result of AbdominoPerineal Extra Levator Resection for Distal Rectal Cancer https://ClinicalTrials.gov/show/NCT01296984 Completed Sahlgrenska University Hospital, Sweden 2014-03-31
NCT02017509 Immunoscore in Rectal Cancer https://ClinicalTrials.gov/show/NCT02017509 Completed Providence Health & Services 2018-07-17
NCT02005965 Low Rectal Cancer Study (MERCURY II) https://ClinicalTrials.gov/show/NCT02005965 Active, not recruiting Royal Marsden NHS Foundation Trust 2016-03-11
NCT01995942 Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural Venous Invasion in Rectal Cancer (MARVEL) Trial https://ClinicalTrials.gov/show/NCT01995942 Active, not recruiting Royal Marsden NHS Foundation Trust 2017-02-02
NCT01987726 Comprehensive Gene Sequencing in Guiding Treatment Recommendations Patients With Metastatic or Recurrent Solid Tumors https://ClinicalTrials.gov/show/NCT01987726 Active, not recruiting Ohio State University Comprehensive Cancer Center 2020-12-31
NCT01835925 Rectal Cancer Consortium https://ClinicalTrials.gov/show/NCT01835925 Completed Brown University 2014-04-30
NCT01816607 Functional MRI of Hypoxia-mediated Rectal Cancer Aggressiveness https://ClinicalTrials.gov/show/NCT01816607 Completed University Hospital, Akershus 2017-12-31
NCT01751516 PET/MRI as a Predictor of Response to Pre-op Chemoradiation in Resectable Rectal Cancer: a Pilot Study https://ClinicalTrials.gov/show/NCT01751516 Active, not recruiting UNC Lineberger Comprehensive Cancer Center 2014-08-31
NCT01721785 Diagnostic Value of Novel MR Imaging Techniques for the Primary Staging and Restaging of Rectal Cancer https://ClinicalTrials.gov/show/NCT01721785 Completed Maastricht University Medical Center 2016-07-31
NCT01671683 Additional Chemotherapy After Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT01671683 Completed Chungnam National University NA
NCT01670851 Perineal Reconstruction Following eLAPE and Simultaneous Stoma Sublay Reinforcement https://ClinicalTrials.gov/show/NCT01670851 Completed University Hospitals, Leicester 2015-09-30
NCT01661829 An RCT for the Effect of Biofeedback Therapy the Prevention of AR Syndrome in Rectal Cancer Patients https://ClinicalTrials.gov/show/NCT01661829 Completed The Catholic University of Korea 2015-02-28
NCT01511653 Validation of Colon Biomarkers for the Early Detection of Colorectal Adenocarcinoma https://ClinicalTrials.gov/show/NCT01511653 Completed University of Michigan 2019-04-30
NCT01477229 Quality of Life in RECTal Cancer - a Prospective Multicenter Cohort Study https://ClinicalTrials.gov/show/NCT01477229 Active, not recruiting Sahlgrenska University Hospital, Sweden 2015-09-30
NCT01460641 Perfusion CT as a Predictor of Treatment Response in Patients With Rectal Cancer https://ClinicalTrials.gov/show/NCT01460641 Completed Stanford University 2016-07-31
NCT01458509 Feasibility and Psychometric Properties of Paper vs. Web vs. Automated Telephone Administration of Patient Reported Outcome Surveys https://ClinicalTrials.gov/show/NCT01458509 Active, not recruiting Memorial Sloan Kettering Cancer Center 2020-10-31
NCT01379612 Ultrasound Elastography in Patients With Rectal Cancer https://ClinicalTrials.gov/show/NCT01379612 Completed Vejle Hospital 2012-06-30
NCT01346280 Evaluation of Cancer Care Coordination in the National Cancer Institutes Community Cancer Center Programs https://ClinicalTrials.gov/show/NCT01346280 Completed National Institutes of Health Clinical Center (CC) NA
NCT01339832 An Observational Study of Xeloda (Capecitabine) and Oxaliplatin Prior and Concurrent To Preoperative Pelvic Radiotherapy in Patients With Locally Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT01339832 Completed Hoffmann-La Roche 2011-12-31
NCT01325649 Optimal Surgery and MRI Based Radiochemotherapy in Rectal Carcinoma https://ClinicalTrials.gov/show/NCT01325649 Completed Johannes Gutenberg University Mainz 2016-09-30
NCT01323166 Quality of Life After Abdominoperineal Resection for Rectal Cancer, Comparing Two Surgical Techniques https://ClinicalTrials.gov/show/NCT01323166 Completed Sahlgrenska University Hospital, Sweden 2011-10-31
NCT04443985 A Cohort of Predictive Factor of Pathologic Complete Response After Preoperative Neoadjuvant in Rectum Cancer https://ClinicalTrials.gov/show/NCT04443985 Recruiting Mahidol University 2020-07-20
NCT04404673 Urinary and Sexual Dysfunctions Evaluation After Rectal Resection https://ClinicalTrials.gov/show/NCT04404673 Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS 2024-02-20
NCT04392609 Predicting Locally Advanced Rectal Cancer Response to NCT and NCRT With MRI https://ClinicalTrials.gov/show/NCT04392609 Recruiting West China Hospital 2020-06-15
NCT04359498 Retrospective Study of Surgical Complications in Patients With Defunctioning Stoma After Low Anterior Resection (LAR) https://ClinicalTrials.gov/show/NCT04359498 Recruiting Safeheal 2020-10-01
NCT04339374 Ultrasound and Photoacoustic Imaging of Colon and Rectal Tumor Tissue https://ClinicalTrials.gov/show/NCT04339374 Recruiting Washington University School of Medicine 2020-12-31
NCT04334421 APEMESH- Preventing Perineal Complications After Abdominoperineal Resection https://ClinicalTrials.gov/show/NCT04334421 Recruiting University of Oulu 2021-05-31
NCT04324567 Inflammation After Laparoscopic Robot-assisted Surgery for Locally Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT04324567 Recruiting Oslo University Hospital 2022-12-31
NCT04293835 Sigmoid Take-off, New Rectum Definition https://ClinicalTrials.gov/show/NCT04293835 Completed Peking University Third Hospital 2019-12-01
NCT04287400 Prospective Trial for the Evaluation of Radiogenomics in Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT04287400 Recruiting National Cancer Center, Korea 2022-02-01
NCT04278274 Post-Neoadjuvant Treatment MRI Based AI System to Predict pCR for Rectal Cancer https://ClinicalTrials.gov/show/NCT04278274 Recruiting Sixth Affiliated Hospital, Sun Yat-sen University 2020-08-08
NCT04273477 Radiomics-based Artificial Intelligence System to Predict Neoadjuvant Treatment Response in Rectal Cancer https://ClinicalTrials.gov/show/NCT04273477 Recruiting Sixth Affiliated Hospital, Sun Yat-sen University 2020-07-31
NCT04273451 RadioPathomics Artificial Intelligence Model to Predict Tumor Regression Grading in Locally Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT04273451 Recruiting Sixth Affiliated Hospital, Sun Yat-sen University 2020-07-31
NCT04271657 RadioPathomics Artificial Intelligence Model to Predict nCRT Response in Locally Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT04271657 Recruiting Sixth Affiliated Hospital, Sun Yat-sen University 2020-07-31
NCT04265417 Clinical Outcomes and Prognostic Factors of Robotic Assisted Rectal Cancer Resection Alone vs. Robotic Rectal Cancer Resection With Natural Orifice Specimen Extraction https://ClinicalTrials.gov/show/NCT04265417 Completed The First Affiliated Hospital of Nanchang University 2016-12-01
NCT04248634 Evaluation of Delayed Coloanal Anastomosis https://ClinicalTrials.gov/show/NCT04248634 Completed Institut National d’Oncologie, Morocco 2019-12-31
NCT04245683 Feasibility of Non-Operative Management of Rectal Cancer in a Rural Population https://ClinicalTrials.gov/show/NCT04245683 Recruiting Bassett Healthcare 2027-02-01
NCT04227886 Study on Predictive Biomarkers of Neoadjuvant Chemoradiotherapy for Rectal Cancer https://ClinicalTrials.gov/show/NCT04227886 Recruiting Fudan University 2020-12-31
NCT04141566 Pseudo Continent Perineal Colostomy vs Permanent Left Iliac Colostomy After Abdominoperineal Resection for Ultra Low Rectal Adenocarcinoma https://ClinicalTrials.gov/show/NCT04141566 Recruiting Moroccan Society of Surgery 2020-06-30
NCT04128657 Validation of the Moroccan Arabic Version of the Low Anterior Resection Syndrome (LARS) and Wexner Score of Continence Among Rectal Cancer Patients https://ClinicalTrials.gov/show/NCT04128657 Completed Moroccan Society of Surgery 2019-10-31
NCT04096118 Relationship Between Lymph Node Ratio and Survival Rate in Preoperative Chemoradiation Rectal Cancer Patients https://ClinicalTrials.gov/show/NCT04096118 Completed Mahidol University 2019-09-30
NCT04095468 Organ-preserving Management in Patients With Complete or Near-complete Tumour Response After Preoperative Radio(Chemo)Therapy for Rectal Cancer https://ClinicalTrials.gov/show/NCT04095468 Recruiting Maria Sklodowska-Curie Institute - Oncology Center 2021-01-01
NCT04088955 A Digimed Oncology PharmacoTherapy Registry https://ClinicalTrials.gov/show/NCT04088955 Active, not recruiting Proteus Digital Health, Inc. 2021-09-30
NCT04006600 Is There a Link Between Anatomical Markers of Surgical Difficulty and Incapacity to Reverse Stoma After Low Rectal Cancer Surgery? https://ClinicalTrials.gov/show/NCT04006600 Recruiting Centre Hospitalier Universitaire de Nīmes 2020-01-15
NCT03996031 Plan to Thrive: Extending Cancer Survivorship Care Beyond the Clinic https://ClinicalTrials.gov/show/NCT03996031 Recruiting Northwestern University 2019-12-31
NCT03962088 Timisnar - Biomarkers Substudy (Timisnar-mirna) https://ClinicalTrials.gov/show/NCT03962088 Recruiting Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria 2023-04-01
NCT03923309 Oncologic Risk of Rectal Preservation Against Medical Advice After Chemoradiotherapy for Rectal Cancer https://ClinicalTrials.gov/show/NCT03923309 Completed Seoul National University Hospital 2017-12-30
NCT03911167 An Analysis of Clinical Efficacy Based on the Robotic, Laparoscopic, and Open Approach in Radical Resection of Rectal Cancer https://ClinicalTrials.gov/show/NCT03911167 Completed First Affiliated Hospital Xi’an Jiaotong University 2018-07-01
NCT03899870 Factors Predicting Recurrence in Rectal Cancer After Surgery https://ClinicalTrials.gov/show/NCT03899870 Completed Université de Sousse 2015-12-31
NCT03896958 The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology) https://ClinicalTrials.gov/show/NCT03896958 Recruiting SpeciCare 2021-03-12
NCT03890926 The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy https://ClinicalTrials.gov/show/NCT03890926 Completed Peking University Third Hospital 2019-02-28
NCT03875612 Radiographic Validation of the Inferior Mesenteric Artery Tie Level in Rectal Cancer Surgery https://ClinicalTrials.gov/show/NCT03875612 Completed Umeå University 2019-08-31
NCT03853733 Hypofractionated Palliative Radiotherapy (39Gy in 13 Fractions) in Patients With Advanced Non-operable Rectal Cancer https://ClinicalTrials.gov/show/NCT03853733 Recruiting Consorci Sanitari de Terrassa 2022-03-01
NCT03846882 FDG - PET / MRI in Patients With Rectal Cancer https://ClinicalTrials.gov/show/NCT03846882 Recruiting Västerbotten County Council 2021-12-31
NCT03846726 Treatment Strategy for Rectal Cancer Patients With Complete Clinical Response https://ClinicalTrials.gov/show/NCT03846726 Active, not recruiting Sun Yat-sen University 2019-02-28
NCT03765736 Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal Cancer for a COLOMATE Trial https://ClinicalTrials.gov/show/NCT03765736 Recruiting Academic and Community Cancer Research United 2023-11-12
NCT03741166 Blood Collection Sub-Study for CRC Screening in Individuals 45-49 at Average Risk for CRC. https://ClinicalTrials.gov/show/NCT03741166 Completed Exact Sciences Corporation 2019-04-05
NCT03731130 Prospective Observational Trial to Evaluate Quality of Life After Neoadjuvant Radiation or Chemoradiation Followed by Surgery in Patients With Rectal Cancer https://ClinicalTrials.gov/show/NCT03731130 Recruiting Ludwig-Maximilians - University of Munich 2021-12-31
NCT03699410 Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can be Predicted With a Particular Blood Test. https://ClinicalTrials.gov/show/NCT03699410 Recruiting Ente Ospedaliero Cantonale, Bellinzona 2020-08-28
NCT03675243 Quality of Life After Transanal Endoscopic Microsurgery (TEM) https://ClinicalTrials.gov/show/NCT03675243 Recruiting State Scientific Centre of Coloproctology, Russian Federation 2020-12-31
NCT03671369 A Post-marketing Surveillance Study to Assess the Safety of Cervarix (GlaxoSmithKline [GSK] Biologicals’ Human Papillomavirus [HPV] -16/18 Vaccine), When Administered According to the Approved Prescribing Information (PI) in Korea https://ClinicalTrials.gov/show/NCT03671369 Active, not recruiting GlaxoSmithKline 2021-02-01
NCT03619668 Chemo-radiotherapy as Main Treatment Strategy for Rectal Cancer. Can we Provide a More Precise and Effective Treatment https://ClinicalTrials.gov/show/NCT03619668 Recruiting Aalborg University Hospital 2020-06-30
NCT03577808 Organoids in Predicting Chemoradiation Sensitivity on Rectal Cancer https://ClinicalTrials.gov/show/NCT03577808 Recruiting Fudan University 2020-08-01
NCT03569488 Validation of the French Version of the Low Anterior Resection Syndrome (LARS) Among Rectal Cancer Patients https://ClinicalTrials.gov/show/NCT03569488 Recruiting University Hospital, Caen 2022-05-30
NCT03601689 Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma https://ClinicalTrials.gov/show/NCT03601689 Completed Moroccan Society of Surgery 2013-12-31
NCT03541304 High Dose Radiotherapy for the Treatment of Rectal Cancer https://ClinicalTrials.gov/show/NCT03541304 Active, not recruiting Sun Yat-sen University 2019-03-30
NCT03516942 Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment https://ClinicalTrials.gov/show/NCT03516942 Recruiting Eastern Cooperative Oncology Group 2023-09-01
NCT03466424 Short-course Radiotherapy (5×6Gy/7Gy/8Gy) Followed by Neo-adjuvant Chemotherapy for Locally Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT03466424 Recruiting Fujian Medical University Union Hospital 2020-06-30
NCT03463616 MRI Imaging or CT Abdomen as Standard Work-up Before Treatment Planning for Rectal Cancer? https://ClinicalTrials.gov/show/NCT03463616 Active, not recruiting Sahlgrenska University Hospital, Sweden 2020-03-31
NCT01216189 Sexual Function and Wellbeing in Females Diagnosed With Rectal Cancer https://ClinicalTrials.gov/show/NCT01216189 Completed Karolinska Institutet 2013-12-31
NCT01181557 A Questionnaire to Assess the Quality of Life of Rectal Cancer Patients With or Without Stoma https://ClinicalTrials.gov/show/NCT01181557 Completed Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 2009-08-31
NCT01125111 The Clinical Study of Making the Evidence With Application of Da Vinci-Robot Assisted Low Anterior Resection in Rectal Cancer https://ClinicalTrials.gov/show/NCT01125111 Completed Yonsei University 2010-03-31
NCT03871790 Peptide-based Immunization for Colon- and and Pancreas-carcinoma https://ClinicalTrials.gov/show/NCT03871790 Recruiting Centogene AG Rostock 2021-04-01
NCT01045200 Nurse-or Surgeon-led Follow-up After Rectal Cancer https://ClinicalTrials.gov/show/NCT01045200 Completed Centrallasarettet Västerås 2004-10-31
NCT01023529 Symptoms and Quality of Life (QoL) After Palliative Pelvic Radiation of Prostate and Rectal Cancers https://ClinicalTrials.gov/show/NCT01023529 Completed Sorlandet Hospital HF 2015-07-31
NCT00972751 S9304A Study of Protein Expression in Tumor Tissue Samples From Patients With Stage II or Stage III Rectal Cancer Enrolled in Clinical Trial SWOG-9304 https://ClinicalTrials.gov/show/NCT00972751 Completed Southwest Oncology Group 2010-09-30
NCT00969657 Validation of a Predictive Model After Complete Response in Rectal Cancer https://ClinicalTrials.gov/show/NCT00969657 Completed Maastricht Radiation Oncology 2011-10-31
NCT00952926 Watchful Waiting. An Observational Study of Patients With Rectal Cancer After Concomitant Radiation and Chemotherapy https://ClinicalTrials.gov/show/NCT00952926 Completed Vejle Hospital 2014-01-31
NCT00910143 Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer https://ClinicalTrials.gov/show/NCT00910143 Completed University Hospital Inselspital, Berne 2001-12-31
NCT04013347 Outcomes of Resection at Different Times Between the End of Neoadjuvant Treatment and Surgery https://ClinicalTrials.gov/show/NCT04013347 Completed Campus Bio-Medico University 2015-03-01
NCT03573791 Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT03573791 Recruiting Wuhan Union Hospital, China 2021-05-21
NCT03336658 Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer https://ClinicalTrials.gov/show/NCT03336658 Recruiting University Hospital Inselspital, Berne 2020-12-31
NCT03314961 Lymph Node Metastases and Arterial Ligation in Rectal Cancer Surgery https://ClinicalTrials.gov/show/NCT03314961 Completed Region Västmanland 2016-12-31
NCT00712751 The Sexual Health of Rectal Cancer Patients https://ClinicalTrials.gov/show/NCT00712751 Active, not recruiting Memorial Sloan Kettering Cancer Center 2021-06-30
NCT00648635 Relationship Between Quality of Life, Treatment Modalities, and Patient Treatment/Outcome Expectations https://ClinicalTrials.gov/show/NCT00648635 Active, not recruiting M.D. Anderson Cancer Center 2021-08-31
NCT00636948 Rectal Cancer Trial On Defunctioning Stoma https://ClinicalTrials.gov/show/NCT00636948 Completed Rectal Cancer Trial on Defunctioning Stoma Study Group 2005-06-30
NCT00579579 Functional Outcomes and Quality of Life in Patients Undergoing Surgery for Rectal Cancer https://ClinicalTrials.gov/show/NCT00579579 Active, not recruiting Memorial Sloan Kettering Cancer Center 2020-12-31
NCT00578838 Magnetic Resonance Study of Liver in Chemotherapy https://ClinicalTrials.gov/show/NCT00578838 Completed Memorial Sloan Kettering Cancer Center 2016-05-31
NCT00549276 Randomized Comparison of Curved Cutter Stapler and Linear Stapler https://ClinicalTrials.gov/show/NCT00549276 Completed Samsung Medical Center NA
NCT01216202 Sexual Function and Wellbeing in Males Diagnosed With Rectal Cancer https://ClinicalTrials.gov/show/NCT01216202 Completed Karolinska Institutet 2014-05-31
NCT00414232 Prospective Assessment of Symptoms and Quality of Life in Rectal Cancer Patients Receiving Chemo-Radiotherapy https://ClinicalTrials.gov/show/NCT00414232 Completed Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2010-10-31
NCT00410579 Patient-Reported Outcomes in Long-Term Survivors of Colon and Rectal Cancers https://ClinicalTrials.gov/show/NCT00410579 Completed NSABP Foundation Inc 2009-02-28
NCT00271986 Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection (LAR) for Recto-sigmoid Cancer https://ClinicalTrials.gov/show/NCT00271986 Completed Odense University Hospital 2007-11-30
NCT00280761 Biomarkers in Patients With Rectal Cancer Undergoing Chemotherapy and Radiation Therapy https://ClinicalTrials.gov/show/NCT00280761 Active, not recruiting UNC Lineberger Comprehensive Cancer Center 2020-12-31
NCT00220181 Prospective Study in Pelvic Radiotherapy Patients https://ClinicalTrials.gov/show/NCT00220181 Completed Royal Marsden NHS Foundation Trust NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT04455945 Quality of Life After Rectal Cancer Surgery https://ClinicalTrials.gov/show/NCT04455945 Completed Dr. Lutfi Kirdar Kartal Training and Research Hospital 2018-12-31
NCT03257332 Determining Early Development of Faecal Incontinence and Anorectal Muscle Function After Surgery for Rectal Cancer. https://ClinicalTrials.gov/show/NCT03257332 Enrolling by invitation Slagelse Hospital 2020-12-31
NCT03253302 Laparoscopic Assisted Transanal Total Mesorectal Excision for Rectal Cancer in Low Site https://ClinicalTrials.gov/show/NCT03253302 Enrolling by invitation Beijing Friendship Hospital 2018-12-31
NCT02979795 Translational Research in Identifying Molecular Mechanisms for Rectal Cancer Metastasis https://ClinicalTrials.gov/show/NCT02979795 Recruiting China Medical University Hospital 2020-11-30
NCT02738359 Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening https://ClinicalTrials.gov/show/NCT02738359 Recruiting Hôpital Edouard Herriot 2020-11-30
NCT02624115 FAZA PET as Biomarker for Hypoxia in Rectal Cancer https://ClinicalTrials.gov/show/NCT02624115 Completed University Health Network, Toronto 2019-06-09
NCT02551471 Benchmarking Trial Between France and Australia Comparing Management of Primary Rectal Cancer Beyond TME (Total Mesorectum Excision) and Locally Recurrent Rectal Cancer https://ClinicalTrials.gov/show/NCT02551471 Completed University Hospital, Bordeaux 2018-05-04
NCT02278653 Functional Outcome of Organ Preservation After Neo-adjuvant Chemo Radiation for Rectal Cancer https://ClinicalTrials.gov/show/NCT02278653 Active, not recruiting Maastricht University Medical Center 2017-10-31
NCT02113384 Locally Advanced Rectal Cancer - Exfoliated Peritoneal Tumor Cells https://ClinicalTrials.gov/show/NCT02113384 Recruiting Oslo University Hospital 2017-01-31
NCT04200027 Robotic vs. TaTME Rectal Surgery (ROTA STUDY) https://ClinicalTrials.gov/show/NCT04200027 Active, not recruiting Odense University Hospital 2022-11-01
NCT04075305 The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study https://ClinicalTrials.gov/show/NCT04075305 Recruiting UMC Utrecht 2024-02-01
NCT03989180 Development Study of Check-Cap Imaging System in Healthy Volunteers https://ClinicalTrials.gov/show/NCT03989180 Recruiting Check-Cap Ltd. 2021-02-02
NCT03874559 Exosomes in Rectal Cancer https://ClinicalTrials.gov/show/NCT03874559 Recruiting University of Kansas Medical Center 2021-02-01
NCT03765411 Safe Colorectal Surgery in the Elderly https://ClinicalTrials.gov/show/NCT03765411 Completed Tripler Army Medical Center 2013-04-15
NCT03688906 AI-EMERGE: Development and Validation of a Multi-analyte, Blood-based Colorectal Cancer Screening Test https://ClinicalTrials.gov/show/NCT03688906 Completed Freenome, Inc. 2019-11-25
NCT03683446 Trends and Outcomes in Laparoscopic Versus Open Surgery for Rectal Cancer https://ClinicalTrials.gov/show/NCT03683446 Completed The Methodist Hospital System 2017-01-30
NCT03615170 Application of Circulating Tumor DNA Test in the Diagnosis and Treatment of Patients With Advanced Rectal Cancer https://ClinicalTrials.gov/show/NCT03615170 Recruiting Zhejiang Cancer Hospital 2020-03-30
NCT03574493 Rectal Surgery Evaluation Trial (RESET) https://ClinicalTrials.gov/show/NCT03574493 Recruiting Institut du Cancer de Montpellier - Val d’Aurelle 2020-06-30
NCT03543514 PREHABILITATION COLORECTAL SURGERY https://ClinicalTrials.gov/show/NCT03543514 Recruiting Corporacion Parc Tauli 2018-12-30
NCT03516916 Surviving Rectal Cancer at the Cost of a Colostomy International Validation of the Colostomy Impact Score https://ClinicalTrials.gov/show/NCT03516916 Enrolling by invitation Aarhus University Hospital 2019-08-31
NCT04456283 Survival of Patients With a Reduction in the Number of Lymph Nodes in Rectal Cancer After Neoadjuvant Chemoradiotherapy https://ClinicalTrials.gov/show/NCT04456283 Recruiting University of Sao Paulo 2020-05-15
NCT03426397 “Wait-and-see” Policy for Complete Responders After Chemoradiotherapy for Rectal Cancer https://ClinicalTrials.gov/show/NCT03426397 Recruiting The Netherlands Cancer Institute 2020-01-01
NCT03416699 Chinese TaTME Registry Collaborative https://ClinicalTrials.gov/show/NCT03416699 Recruiting Beijing Friendship Hospital 2018-11-15
NCT03452774 SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry https://ClinicalTrials.gov/show/NCT03452774 Recruiting Massive Bio, Inc. 2021-12-31